Caspase 1, Human Recombinant
$502.41
| Size |
25 Units |
|---|
Caspase 1, Human Recombinant
General description
Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. Active Caspase-1 is a heterotetrametric molecule consisting of two large and two small subunits. To date, the regulatory mechanism of Caspase-1 activation and its role in apoptosis are poorly understood. In THP-1 cells, a large proportion of the Caspase-1 is present in the inactive proenzyme form. The recombinant active human Caspase-1 was expressed in E. coli. The active Caspase-1 preferentially cleaves Caspase-1 substrates (e.g., YVAD-AFC or YVAD-pNA). The rh-Caspase has an N-terminal His-tag and corresponds to amino acids 120-404 of Caspase-1, gene accession# NP_150634.1.
Synonyms:Â Â Â Â Â Â Â Â Â Â Â Â Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, IL-1 beta-converting enzyme, p45
Gene Symbol:Â Â Â Â Â Â Â Â Â Â CASP1
Gene ID:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 834
Source:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â E. coli.
Form:Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Lyophilized powder
Molecular Weight:Â Â Â Â Â Â Large (20 kDa) and small (10 kDa) subunit
Reconstitution Inst.:      Reconstitute to 1 unit per µl in water
Handling:Â Â Â Â Â Â Â Â Â Â Â Â Â Centrifuge the vial prior to opening
Storage temp.:         -70°C
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MAECENAS IACULIS
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ADIPISCING CONVALLIS BULUM
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