Caspase 8, Human Recombinant

Caspase 8, Human Recombinant

General description

Caspase-8 (also known as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, Caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of Caspase-8 consists of large and small subunits which associate to form the active enzyme. Active Caspase-8 has been shown to activate Caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active human Caspase-8 was expressed in E. coli.

Synonyms:                       Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog

Gene Symbol:                  CASP8

Gene ID:                            841

Source:                              E. coli.

Form:                                 Lyophilized powder

Reconstitution Inst.:       Reconstitute to 1 unit per µl in PBS containing 15% glycerol

Handling:                          Centrifuge the vial prior to opening

Storage temp.:                 -70°C