Gentamicin sulfate, USP Grade

General Description

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora and is used as the sulfate salt. Aminoglycoside antibiotics are composed of amino groups attached to glycosides. This antibiotic functions by preventing protein synthesis. It binds the 30s ribosomal subunit, causing misreading of the mRNA sequence, inhibition of translocation, and consequently, the protein synthesis is inhibited. Gentamicin sulfate prevents the growth of both Gram positive (+) and Gram negative (-) bacteria, in vivo and in vitro. In tissue culture, Gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma. Gentamicin is a broad-spectrum antibiotic and also exhibits antimicrobial properties against species resistant to tetracycline, colistin, kanamycin, and chloramphenicol.

CAS Number:                1405-41-0;